Intervju 1 (av 2)

Dr John Lee Medical Letters (JLML) is  interviewing dr C.W. Randolph (CWR).

C.W. (Randy) Randolph, M.D. has been in medical practice near Jacksonville, Florida for more than fifteen years. His practice includes gynaecology, uro-gynaecology, infertility and natural hormone balance. He has also been a compounding pharmacist since 1972. Randolph uses bio-identical hormones to treat women with hormone imbalances, and as a result has a very busy medical practice.

JLML: Dr. Randolph, I imagine you’ve been very busy, as we have, since the announcement that the PremPro arm of the Women’s Health Initiative study was cancelled due to much higher rates of breast cancer, heart disease and strokes among women using PremPro.

CWR: Yes, the phone’s been ringing off the hook, and I’m going to be on the local news tonight talking about it. I’m so busy that my first available appointment is around Thanksgiving. Using natural hormones has made the practice of medicine very rewarding, and my four nurse practitioners feel the same way. There’s nothing better than getting consistently positive feedback from your patients, and seeing them healthy and happy.

JLML: All of the physicians we know who are using natural hormones have very, very busy practices and are once again enjoying being in medicine. We interviewed you about two years ago, and you’ve been using natural hormones for about five years. Is there anything that you’ve observed as you’ve treated thousands of women over the past two years, that you’d like to share with our readers?

CWR: I’ve seen numerous cases where osteoporosis has improved with natural progesterone and/or natural hormones in general. A lot of my patients are on bi-est [estradiol and estriol cream], natural progesterone, and testosterone for hormonal balance. Some who have had breast cancer are just on the natural progesterone. I had a lady in yesterday who has been on my regimen for a year, and she went from a -3.6 on her spine to 2.5. The hip was a little bit less, a -2.7 to a 1.8. I continually see those kinds of results. I had another lady who had a 40 percent bone loss and gained 17 percent of it back in a year.

JLML: Do you see greater improvement in bone density in the older ladies, say over the age of 60, than those who are in perimenopause?

CWR: Yes, definitely. What I’ve found is that if bone density is low, using natural hormones improves it, but if it isn’t low – in other words it’s normal – bone density doesn’t increase. In other words, if a woman doesn’t have much bone loss her bone density doesn’t increase much, if at all. Why would it? Since the osteoporosis and progesterone cream study done by Dr. Helene Leonetti a few years back was primarily with women in perimenopause who had little or no bone loss, the women using progesterone cream didn’t come out very different from those who weren’t using it. It was a good study, but misleading in a way. We need a study done with progesterone cream on women who do have measurable bone loss.

JLML: Because of that study, I’ve been criticized for my claims that progesterone increases bone density, so I’d certainly like to see another one with older women who have measurable bone loss. Have you had much breast, endometrial or ovarian cancer in your practice since you started using natural hormones?

CWR: I have not had any patients on natural hormones develop endometrial or ovarian cancer. In fact, I had a patient come to me who had been diagnosed with endometrial hyperplasia with atypia, which is a pre-cancerous lesion of the endometrium, and she did not want to be treated with Provera. I put her on natural progesterone. She came back in three months, I did a biopsy of the lining of the uterus, and it was entirely normal. At six months I did another biopsy, and again it was entirely normal. Two patients who had both been on Premarin, one for 30 years and the other for 22 years, did get breast cancer. I had just converted them over to natural progesterone cream when the cancer was detected. Of course you know that if you have been diagnosed with breast cancer today, it’s been there a long time – at least 7 years, maybe 10. In the past several years I’ve had numerous patients come to me who have had breast cancer, some of whom are on tamoxifen. I put them on progesterone cream, and have not had any patients who have had a recurrence. The other thing I’ve noticed is that a lot of my patients are able to get off Prozac and other antidepressants after a few months of using natural hormones. What typically happens is that a patient goes to her doctor and complains of depression, lack of energy, and weight gain, for example. The doctor will do a blood test, it will come back normal, and then he will offer the patient some Prozac. Yet all they needed was some progesterone! I do a saliva test on these patients and they’re extremely deficient in progesterone – their body is just craving it. I see that a lot. They get on the progesterone and within six to eight weeks they can get off their antidepressant. Insomnia that started with menopause also tends to be resolved very quickly after starting on natural progesterone. And women who have been estrogen dominant, or have gained weight on synthetic hormones, have a greater tendency to be able to lose weight once their hormones are balanced.

JLML: Do you see many women who have side effects when they use progesterone cream?

CWR: Not many, but there is a small subset of women who try progesterone cream and they’ll feel worse or get breast tenderness. These are primarily women who aren’t using the cream regularly, or who are cigarette smokers. There are over 130 toxins in cigarettes, and your liver is constantly trying to metabolize all these toxins out of your bloodstream. I think that in part has an effect on the way that the liver metabolizes progesterone.

JLML: Do you work with patients who have post partum depression?

CWR: I don’t see many patients who are freshly post partum, but many are referred to me after six weeks or so, and progesterone definitely does help them. Dr. Katherina Dalton, in London, says that in women with a history of post partum depression, the progesterone should be started as soon as the umbilical cord is clamped. She uses vaginal suppositories.

CWR: I don’t see many patients who are freshly post partum, but many are referred to me after six weeks or so, and progesterone definitely does help them. Dr. Katherina Dalton, in London, says that in women with a history of post partum depression, the progesterone should be started as soon as the umbilical cord is clamped. She uses vaginal suppositories.

JLML: How about cognitive changes in older women with dementia or senility?

CWR: I do see a marked improvement in cognitive ability in a lot of patients, and not just older patients. This is especially true of women who also need estrogen and testosterone.

JLML: What kind of progesterone cream do you use?

CWR: Being a compounding pharmacist, I’ve developed a cream that’s very pure and doesn’t contain any active ingredients besides progesterone. A lot of the creams on the market contain phytoestrogens such as black cohosh, dong quai, chaste berry, red clover and so forth. Don’t get me wrong, I’m not against phytoestrogens – they have their place. But you can’t give those hormones in pregnancy because they can cause the uterus to contract and cause the patient to miscarry. I don’t do obstetrics anymore, but I do work with infertility, and when I’m trying to help my patient get pregnant and she needs progesterone, I want a cream that a pregnant woman can use.

JLML: What is your protocol for getting a woman off PremPro?

CWR: Let’s say that a woman comes in who has been on PremPro for ten years. I explain to her that her liver has been trying to detoxify this horse estrogen for ten years, and is cranking as hard as it can crank to handle this estrogen that is unlike anything that should be in the body. I put them on an equivalent does of estradiol and natural progesterone cream, which is 1 mg of estradiol daily, and 25 mg of natural progesterone twice daily. In six weeks I see them again and reduce the amount of estrogen to 0.5 mg daily. However, if they’ve been on Premarin for more than 10 years, I will continue them on estradiol for 12 weeks, along with the progesterone, and then will reduce it to 0.5 mg of estradiol, with the progesterone.

JLML: Are there any issues around natural hormones that you’re particularly interested in?

CWR: Yes, the contention by some people that progesterone cream doesn’t get into the uterus and protect it from the potential cancer-causing effects of estrogen. Transdermal [delivered through the skin] progesterone enters the blood within seconds and from there begins to be delivered to tissues throughout the body, so it seems obvious to me that it would protect the uterus, just as progesterone that comes from the ovaries protects the uterus. Conventional medicine is now using progestin patches to protect the uterus, and of course that’s also transdermal delivery. And all of the other hormones are now delivered transdermally in conventional medicine, but for some reason people get stuck on this issue of uterine protection with progesterone cream. To resolve this issue, I want to do a study where we take a sample of the uterine lining, give the patient some natural progesterone cream, have them come back in three or four hours and take another sample. We’ll send these samples off to a lab and have them tested for progesterone levels, just to resolve this question once and for all.

JLML: Most interesting, thank you Dr. Randolph

Interview 2

Dr. John Lee Interviewed by Fay Wertheimer

Interview with John Lee M.D. – International Best Selling Author of the “What Your Doctor May Not Tell You” series, by Fay Wertheimer. Since 1978, US hormone expert Dr. John Lee has advocated Natural Progesterone as a treatment instead of HRT for menopausal and post-menopausal women. Natural Progesterone, unlike Oestrogen-based therapies, has no side effects.

Fay: What are you beliefs regarding HRT?

Dr. Lee: I consider Oestrogen-based HRT in its present form to be dangerous. The dosage of HRT’s components is 8 to 10 times higher than necessary for many women and HRT cannot easily be adapted to suit individuals’ requirements. Women on Oestrogen are 300% more likely to suffer strokes than others and excessive Oestrogen, known to be the sole cause of uterine cancer, has direct links with breast and ovarian cancers. In fact, taking unopposed Oestrogen’s accounts for over 50% of ovarian cancers..

Fay: That’s pretty strong. Aren’t you being an alarmist?

Dr. Lee: No, I’m telling the truth. Women can do themselves no better a favour than to ask doctors to prescribe them Natural Progesterone and to lower their intake of Oestrogen-based therapies.

Fay: Doesn’t HRT contain Progesterone as well as Oestrogen?

Dr. Lee: HRT contains a synthetic product, an imitation of Natural Progesterone but NOT Natural Progesterone.

Fay: What do you mean by Natural Progesterone?

Dr. Lee: It’s a hormone natural to humans, which scientists can make from plant fats and oils. It’s most effective when applied as a cream but it can be dissolved in drops or capsules. When the technique for making Natural Progesterone was discovered in 1937 by Professor Marker at Pennsylvania University, the price of Progesterone dropped from $35,000 a pound to $7 pound.

Fay: Why should doctors prescribe Progesterone in the first place?

Dr. Lee: Because Progesterone, NOT Oestrogen is the hormone lacking in menopausal and post-menopausal women. Ovaries don’t die or disappear; they just reduce their Oestrogen production. Women into their 80s still make their own Oestrogen as a recent survey confirmed. It is Progesterone which should be replaced.

Fay: Surely medics have noticed this by now?

Dr. Lee: Sadly, they rarely measure Progesterone levels but focus upon Oestrogens. I think any Progesterone-deficient woman should be able to restore her hormonal balance in the same way as someone with an insulin or thyroid-deficiency.

Fay: Are doctors being negligent?

Dr. Lee: No. They are being bombarded by the pharmaceutical industry’s misleading if not false advertising. Oestrogen-based drug sales bring in more revenue than any other, so manufacturers want all women put on HRT, ERT and the contraceptive pill. The supposed benefits of Oestrogen are so convincingly portrayed that practitioners are unaware these ‘benefits’ are far outweighed by the dangers of giving unopposed Oestrogen.

Fay: How did you become involved in women’s hormonal treatment?

Dr. Lee: In the mid-70s, experts realised women taking Oestrogen replacement therapy (ERT) for menopausal symptoms and the prevention of osteoporosis were 6 times more likely to develop endometrial cancers than other women. I’d been in family practice in Mill Valley California since 1958. ERT had been in use since 1951. I started thinking more deeply about what I thought hormone replacement should be. I was very concerned. What was I to give osteoporosis patients if they already had a history of breast or endometrial cancer? I began exploring both mainstream and alternative medicine for solutions.

Fay: When did Progesterone come into the equation?

Dr. Lee: It was noted that women with good Progesterone levels never developed uterine cancers so pharmaceutical companies started manufacturing synthetic Progestins to imitate Natural Progesterone. They combined their product with estrogen hence HRT.

Fay: What’s wrong with that?

Dr. Lee: Many patients suffered side effects as none of the imitation products could convey all the benefits of the unique, Natural Progesterone.

Fay: Please define further what you mean by Natural Progesterone?

Dr. Lee: I refer to a substance natural to humans and identical to the Progesterone molecules made by women’s ovaries and men’s testes. There are receptors for Progesterone in all tissues of the body such as the brain, the white cells not just the uterus. The body needs Progesterone.

Fay: Can men take Natural Progesterone?

Dr. Lee: Of course. I take it to ward off heart disease, prostate cancer and stroke. The premature deaths of my father, uncle and cousin they all died before they were 50 stimulated my interest in preventatives.

Fay: As a Harvard-trained medic, you could have specialised but you opted instead for family practice – why is that?

Dr. Lee: Specialists limit themselves to just specific body parts but family practice is a specialism looking at the whole person. As a family practitioner for 31 years, I was able to treat patients holistically. As Hippocrates said:’Tell me where this man is from and what he does and I will learn more about his illness. I understood patients fully.’

Fay: When did you first prescribe Natural Progesterone?

Dr. Lee: In 1978, a biochemist’s lecture convinced me of the healing potential of Natural Progesterone however I would not offer it to my patients before thoroughly researching the hormone. The abundance of detailed documentation and positive feedback amazed me. Everything had already been scientifically validated yet medical schools made no mention of Natural Progesterone. I then gradually put women with breast cancer, blood disorders, heart conditions and stroke onto Natural Progesterone. For those with brittle bones I combined the Progesterone with low-dose Oestrogens.

Fay: How did you become a crusader?

Dr. Lee: Every patient reported health benefits over and above my expectations headaches vanished, joints improved, bone densities thickened, libido returned, fibro-cystic breasts returned to normal, energy increased and sleep improved. Each anecdotal report could be supported with scientific evidence.

Fay: How did colleagues react?

Dr. Lee: They were cautious but curious, never administering it to patients but always keen for me to sort out their own families’ hormonal problems.

Fay: And now?

Dr. Lee: Conventional medicine acknowledges the dangers of Oestrogen-dominance and Progesterone-deficiency yet still will not disseminate the facts about Natural Progesterone. This may be due to pressure from the pharmaceutical companies who cannot patent Natural Progesterone and want doctors to prescribe their products.

Fay: In 1993, your first book ‘What Your Doctor May Not Tell You About The Menopause’ was published. How accurate are your findings?

Dr. Lee: No doctor has found any error in my research. On the contrary, doctors prescribing Progesterone have invariably called to confirm their patients’ improvement in health.

Fay: What are the side effects of Natural Progesterone?

Dr. Lee: None. The name ‘Progesterone’ may imply a purely pro-gestation hormone – one to aid reproduction – but Natural Progesterone can be taken indefinitely.

Fay: What is your financial involvement in the Natural Progesterone?

Dr. Lee: I have no monetary interest in this at all. Rumours were spread I was the Chinese owner of all the Progesterone companies but I’m a family doctor of Norwegian -Swedish stock – with a mission..

Fay: Which is?

Dr. Lee: Showing people how to become healthy through good diet, exercise, nutrition, better responses to stress and the use of Progesterone supplements. Getting patients to ask their doctors for Natural Progesterone. Educating Doctors about prescribing Natural Progesterone creams instead of the synthetic versions. You see, true medicine is not merely treating the symptoms of illness but finding the underlying metabolic causes of that illness and then fixing them.

Fay: How can women access Natural Progesterone in Europe?

Dr. Lee: If they contact the Well Woman’s Information Service they will send them out a comprehensive pack that contains everything they need to know.

Fay Wertheimer 2001. I interviewed Dr. John Lee on the 21 st May 2001 and verify that this is a true transcript of the tape.